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HairSite - Women's Hair Care and Hair Loss Forums
Topic F209 - Aldactone or Spironolactone - forum # 6

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From: Ieve
Date: 12 Aug 2001
Time: 16:31:30
Remote Name: 62.83.14.6

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I have found this info, I think most of you have read it but I send it anyway. -------------------------------------------------- Hair loss specialists are currently using the treatment protocol below to treat AGA.

To effectively treat your androgenetic alopecia, there are now two classes of drugs available:

1) A growth stimulant to extend the anagen phase of the growth cycle. (Minoxidil is the only FDA proven and approved hair growth stimulant. The results are dose related. The higher the concentration the better the response is to treatment.)

2) An anti-androgen to decrease or remove DHT from the androgen receptor sites of the susceptible scalp follicles. If your hair follicles are deprived of DHT, your hair follicles stop atrophying.

This combination is the only proven, safe and effective therapy to prevent or reverse androgenic alopecia.

There are many drugs effective in reducing the levels of DHT and more drugs are currently being clinically tested. Our current recommendations include the following:

1.) Finasteride (Propecia/Proscar) is an oral medication manufactured by Merck Pharmaceuticals. It lowers the serum level of DHT 50 to 70% and inhibits one of the two enzymes that converts testosterone to DHT. This drug is not recommended for women of child bearing age, because there is a theoretical risk of birth defects to the male fetus.

2) Spironolactone can be used as a topical medication. It blocks the androgen receptor sites from DHT. Women can also take oral spironolactone; it helps about 50% of female patients. Men should not use oral spironolactone, because of its feminizing effects. (applied topically, spironolactone does not have any systemic side effects)

3) Azelaic acid is a topical medication. It removes greater than 98% of scalp DHT where it is applied. This drug is effective for both men and women.

You could use a combination of 5% minoxidil and topocal 2%spironolactone. Spironolactone should not be combined with minoxidil in solution, otherwise they would react and emit an offensive odor. However, the two solutions can be applied to the scalp in succession without compromising the pharmacologic action of either medication. Minoxidil should be applied morning and evening. Spironolactone should be applied once a day, preferably in the evening.

Being only on Minoxidil is only half treating the problem. DHT is deadly to your hair.

Good news is that hair follicles DO have the inherent capacity to mature back to their former size but they can't when DHT is attaching to them.

Cortney

From: Bradley
Date: 24 Dec 2006
Time: 04:54:31
Remote Name: 203.144.143.7

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HairSite - Women's Hair Care and Hair Loss Forums Topic F209 - Aldactone or Spironolactone - forum # 6