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Voted # 1 for 4 consecutive years. Richard Farrell redefining non-surgical hair replacement !! |
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From: waseda
Date: 28 May 2001
Time: 12:12:02
Remote Name: 211.13.141.244
I hear some companies ask Pola to offer the S-maltoside and Pola rejects it for the time being.
But, perhaps Pola will be undurable against the perssure from such big business. In addition, Pola seems to have the next promising stuff, FGF-5S inducer from plant resource. I guess strengthening will be done when they add the inducer and supply S-maltoside for other companies in two years. Because I personally speculate the manufacturing of FGF5-S might be coming in two years.
J Invest Dermatol 2000 Mar;114(3):456-63
Dual-mode regulation of hair growth cycle by two Fgf-5 gene products.
Suzuki S, Ota Y, Ozawa K, Imamura T
POLA R&D Laboratories, Totsuka-ku Yokohama, Japan.
As the result of alternative mRNA splicing, Fgf-5, the gene encoding fibroblast growth factor-5, translates to both long and short forms of the protein, respectively, designated fibroblast growth factor-5 and fibroblast growth factor-5S. We previously showed that localization of fibroblast growth factor-5 and the level of fibroblast growth factor-5S in murine skin are hair-cycle dependent. In this study, we examined the effect of fibroblast growth factor-5 and fibroblast growth factor-5S on the hair growth cycle in mice. Once the anagen phase of the hair growth cycle was induced in the dorsal skin by depilation during telogen, and effects of subcutaneous injection of fibroblast growth factor-5 and fibroblast growth factor-5S into the affected region were analyzed. We found that fibroblast growth factor-5 inhibited hair growth during anagen and promoted the transition from anagen to catagen. Interestingly, whereas fibroblast growth factor-5S alone exerted no effect on hair growth, it significantly inhibited the catagen-promoting activity of fibroblast growth factor-5 when the two proteins were injected simultaneously. Because neither fibroblast growth factor-5 nor fibroblast growth factor-5S affected skin thickness, it is postulated that changes in skin thickness during hair cycle are separately regulated by factors other than those regulating hair and follicle growth. The present results, together with our earlier findings that fibroblast growth factor-5-producing cells gather around dermal papillae during catagen, whereas fibroblast growth factor-5S is abundantly expressed in the hair follicles only during the latter half of anagen, suggests that the mouse hair growth cycle is regulated by the two Fgf-5 gene products acting in concert: fibroblast growth factor-5 induces catagen, whereas fibroblast growth factor-5S antagonizes this activity during anagen.
PMID: 10692103
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