Topic 408 - RU58841 (forum # 7)

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Re: Some comments on topical flutamide.

From: RSanders
Date: 25 May 2001
Time: 11:28:52
Remote Name: 128.151.144.52

Comments

Wow, how did I miss this one?

<<I can only think of a couple of ways to explain this result: a) flutamide gets hydroxylated in the skin by local enzymes, just like it does in the liver when taken systemically>>

I think this is probably what happens- the amount of flutmide ending up in the bloodstream is going to be miniscule from a topical application. A few mgs, tops- certainly not enough to profoundly affect sebaceous gland activity.

<<b) just like I've been pointing out in the animal experiments for a long time, topical flutamide in humans also works only to the extent that it gets absorbed systemically; in which case, it passes through the liver and gets hydroxylated there as usual, and only then does it have its effect on the sebaceous glands in a systemic fashion.>>

As I said above, I find this unlikely, but who knows....

<<Fortunately, though, I AM going to do my own test of flutamide that way! (BTW, I personally lean toward this second explanation.)>>

Have you purchased any flutamide yet? If not, I'd be happy to send you some of mine. I don't see any reason for you to shell out $300 for a drug you're only going to use a gram or so of.

<<The third interesting thing is the claim they make in the Discussion section: "Furthermore, the [sebaceous gland] response to androgens is dependent on the state of sebaceous activity, and we have found that intradermal androgen decreases sebaceous lipogenesis when basal rates of SER are high and increases it when they are low..." >>

Ah! Now I see why 11-alpha HP *increased* sebum production in that lone test subject! Some sort of feedback mechanism at work, apparently. How interesting.

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