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From:
Date: 31 May 2001
Time: 17:08:28
Remote Name: 198.81.16.34
Re: RU58841, flutamide, or castration: which is more effect... From: Bryan Date: 31 May 2001 Time: 16:36:25 Remote Name: 206.138.228.238
>>>I don't CARE how suitable it is for a human hair model. Again, the point is that castration is a VERY POWERFUL means of reducing androgenic stimulation. And quite possibly, more powerful than either RU58841 or flutamide.>>>
The point is still being lost on you that you are comparing animal castration to human castration in terms of how animal/human castration applies to animals ears/flanks/glands as opposed to HUMAN hair. It's a no-go. Once again, Casodex is 3 times stronger than hydroxyflutamide, but in PC3 cells with WT ARs that all changes and hydroxyflutamide becomes more powerful than Casodex. A complete reversal of the results when you use androgen in different locations. Human hair may not have the upper limit of androgen suppression when antiandrogen therapy is applied so the right antiandrogen therapy may go further in reversing hairloss than castration. We already know there's still plenty of androgen in the body after castration.
>>>You continue to evade the point, which is that even if I'm wrong about castration being the MOST powerful "antiandrogen", it is still right up there NEAR the top. That's what I've been trying to convince maneless of for the past year. He has always ignored the fact that castration in humans doesn't regrow hair, saying that it's nowhere near the effect of RU58841. This evidence which I've presented destroys that notion.>>>
Castration leaves behind plenty of androgens as I have told you numerous times and as you yourself have admitted numerous times. Castration leaves behind a ton of androgen.
>>>I tend to take anecdotes reported on the Internet with a grain of salt, especially anonymous ones. I always point to a post I saw once on alt.baldspot from a guy who said, "I started using aloe vera and salt two weeks ago, and now I'm seeing new hairs popping up on my hairline!" I kid you not! Those were almost his EXACT words! ;-)>>>
Sure you think rodent castration is the same as human castration concerning its' affects on rodent ears, flank organs, etc as opposed to human hair, but you know that Mohawk and "Anonymous" are liars. I thought they sounded credible. I don't think it sounds credible to compare rodent castration to human castration concerning affectation on rodent ears/flank organs to human hair, especailly when we are really talking about antiandrogens, and not castration. We got a billion things going on here. It's getting convoluted.
BTW, as Mike (emkaypee) pointed out to maneless on alt.baldspot a few months ago, there have in fact been reports there in the past on the newsgroup from people who managed to get RU58841 synthesized, and they had no response from it. So add those to your statistics!
Bryan
Those people got ripped off Bryan, except for Mohawk and anonymous.
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