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Re: RU58841

From: maneless to RSanders
Date: 20 Jun 2001
Time: 17:35:02
Remote Name: 64.12.101.177

Comments

>>>From: RSanders>>>

>>>It's probably not as sinister as it sounds; they're probably talking about androgen-dependent cancers like prostate cancer, which are typically treated with oral antiandrogens like flutamide and its derivatives. These compounds work pretty well as it stands, so it isn't as though people are dying left and right because Roussel-Uclaf isn't developing these antiandrogenic compounds. Maybe some of the compounds listed in the Roussel-Uclaf patent could be used for prostate cancer, I don't know. The one we're interested in - RU58841 - is designed to be a *topical* antiandrogen, not oral. I'm not sure what sort of activity it would have used orally- maybe Soulpt could comment more on this....>>>

The mere fact that Ochem needs to have the reason explained to him why RU is not a viable treatment for these cancers really damages Ochems credibility. We have been talking about this drug being a topical agent and that it has to be kept out of the body, and yet he doesn't seem to understand this point. He does not seem like a grad student in organic chemistry to me. Of course he should know we are talking about a topical. Of course he should know we are trying to keep the drug out of the body. Of course he should know that the cancers an antiandrogen could treat would be inside the body.

He does not seem to be a real organic chemist in his graduate work. It's very doubtful. He made all kinds of statements in his original outbursts that also didn't seem real plausible that a grad student in org chemistry would've been making.

I'm starting to think that he's just some guy who knows nothing about org chemistry and yet he's hoping that if he has the instructions he can make this stuff in his bath-tub.

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