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Topic 430 - Dutasteride (forum # 9)

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Re: Propecia 5 year study results confirm importance of type ...

From: Soulpt
Date: 26 Jun 2001
Time: 19:37:47
Remote Name: 24.169.222.245

Comments

<<Obviously, you didn't know that. You and Bryan are the ones comparing two very different drugs to each other.>>

Wrong, Glaxo is the one who decided to compare the drugs. We're analyzing the data. Why would they compare it to Finasteride if they were so *very* different. That would be apples to oranges. Isn't this obvious to you?

<<No, I just like By the way, the fact that your nitpicking little mistakes like that proves that you are incapable of addressing the more important facts that I bring to light.>>

I've been the one addressing the science while while you've been busy making outrageous claims on data that doesn't exist. You're so caught up that you can't even see the real issues. Try spending time analyzing what does exist instead of guessing.

<<A type 2 inhibitor and a dual inhibitor have similar modes of action? LOL!>>

Yes. They both block the 5 alpha reductase enzyme (i.e. mode of action). Do you know what "modes of action" means? Is that what threw you?

<<How can that be? They do dramatically different things.>>

"Dramatically different"? Are you kidding? For starters they both inhibit the 5AR enzyme. One to a greater extent then another. In case you didn't know Finasteride (at very high doses) is capable of blocking Type 1 5 AR. FYI that came from Rittmaser directly. But I digress......

<<The limited data we have proves that dutasteride is capable of much greater scalp DHT inhibition than finasteride 5mg.>>

Thanks. Again I knew that.

<<You call that similar? You must be joking.>>

Like I said the "mode of action" is similar. Please pay attention.

<<DHT is the main culprit when it comes to hairloss.>>

Yes. It starts the process moving forward. At a certain point in MPB eliminating even 100% of it won't bring back all that you or I lost. This is the point.

<<As far as RU58841 is concerned, how can I get involved to help it get approved?>>

For starters you could wake up and realize that without blocking other androgens, not just DHT, real regrowth won't be a reality. Then maybe you'd figure out that Dutasteride is only one piece of the puzzle.

Dutasteride & Finasteride work *indirectly* to reverese & prevent hair loss. At best they only block DHT. You seem to think that all the other androgen will just sit there and not bind to the androgen receptor. The problem is really your focus.

<<Telepathic?! I just don't understand that comment.>>

I should have been more specific. You can time traveling (by knowing what extended studies of Dutasteride will produce), are telepathic (are able to read my mind & Bryan's as to what our intentions are), & are clairvoyant (know everything about hair loss). But somehow you can't figure out that other androgens & resulting fibrosis will limit the effectiveness of Dutasteride.

<<Non-scientific nonsense? I think you are getting a little hot under the collar.>>

Again, what are your qualifications?

<<Do you believe comparing two totally different drugs like you and Bryan do scientific?>>

Your proving my point every minute. They aren't that different at all. Everbody here knows this except you.

<<Give me a break, Waseda's opinion casts a new light on the type 1 & 2 enzymes and their effects on hairloss.>>

And what exact high tech equipment & scientific equipment did he use to determine this.

<<I don't know why you cling to that supposed email from Rittmaster. His supposed answer was 'UNKNOWN'. In other words he himself is unsure.>>

The exact quote is "Uknown, but I doubt it". But you are more sure than he is. That's what's so funny. You trust Sawaya's word based on the fact that she was "there" but not Rittmaster's. Absolutely hillarious!!

<<I know for certain because like Waseda I believe there are different types of hairloss and the type 1 & 2 enzyme effect them differently.>>

Great "scientific" analysis. Different "types of hair loss? Effect "them" differently? What are you saying?

Again you know for certain because of Waseda. Do you realize what you are saying? You believe Rittmaster when he says most DHT in the scalp come from Type 1 5AR but completely dissmiss his doubts when it suits you.

<<Knowing this makes me confident to say that a dual inhibitor like Dutasteride will have a more thorough effect in stopping hairloss and regrowing hair.>>

I agree with what you just said above. I have all along.

I'd still like to know why your so confident but Rittmaster isn't? Can you explain that to me?

Soulpt

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