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Topic M446 - Hair Multiplication & Other Advanced Treatments (forum # 38)

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UNGER INFO!

From: Vukodlak
Remote Name: 209.122.237.223
Date: 17 Jul 2001
Time: 22:24:43

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Information is dated 2000.

13. What is the status of culturing hair cells to produce an unlimited amount of donor hair?

In the early 1980's scientists found that they could remove cells from the base of a growing hair and culture that cell to produce millions of cells from it. This work has been done on mice and rats whose hair follicles are not that much different from humans. At our office in Toronto, Canada, my partner Dr. Walter Unger has spear-headed a study in association with Dr. Dan Sauder, Professor of Medicine at the University of Toronto, in addition to procuring funds for the study from anonymous donations, that is attempting to multiply and culture hair matrix cells.

Dr. Walter Unger and Dr. Dan Sauder along with a team of researchers through the University of Toronto have completed the first phase of a 5-step plan. They have been able to identify and grow dermal papilla cells (DPC) and are now ready to start animal studies and then human studies.

For the animal studies athymic mice whose compromised immune systems are less likely to reject foreign material are being employed. Once these researchers can demonstrate that these cells can produce hairs successfully in such mice, and then in humans, the ultimate challenge is to devise an optimal method for introducing the DPC into the human donor. The end goal of course is that instead of depending on a time consuming method of donor hair harvesting and limited supplies of donor hair that we have now, we will be able to have an easily accessed unlimited supply of donor hair. Dr. Unger explains that finding the right cell and the right "food" for that cell took over a year. Similar studies are being conducted in Japan and The Netherlands. Once the cells are reintroduced into the human scalp there is the concern of growing the hair in the right direction and at the right angle.

The studies in athymic mice will be conducted once we receive approval from the Ethics Committee at the University of Toronto. If the mice destroy the foreign tissue the studies will have to be done in more immunilogically compromised mice which will require more time and money, and which will delay human studies. If this works in mice, it is of course uncertain if will work in the human donor. However, it is likely that if these cells grow hairs in a mouse it will also grow hairs in the donor from whom they were obtained. It is likely to be a year or two before we will know whether we can accomplish hair growth from dermal papilla cells or a mixture of these cells and other cells found at the base of the hair.

Patients who are currently having transplants at our office, at their request, are having one of their grafts used to provide dermal papilla cells for them in the future - should this technique become feasible. No other patients are being accepted into the study at this time. ----------------------------------

Dr. Unger's Website:

Beginning at the University of Toronto in 1998, Dr. Unger co-directed studies on what is popularly called 'cloning of hair' but is more accurately called 'cell therapy'. Cells are removed from a patient's hair and millions of similar cells can be reproduced within several weeks. These cells, when injected into immune-compromised mice, can produce hair. The ultimate objective is to inject them back into the human donor and grow unlimited amounts of hair.

Because the technique has not yet been perfected and clearance for human testing by the University Ethics Committee cannot be obtained until it is, human studies have not started. Scientists elsewhere are also working on this project but, thus far, nobody has successfully used this type of 'cell therapy' in humans. -------------------------------------------------

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Re: Great News

From: Date: 26 May 2000 Time: 16:12:52 Remote Name: spider-wo032.proxy.aol.com

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I hope it's true too, but I received an email from Dr. Walter Unger in Toronto last week that stated he still was about 6 months to two years away from beginning human trials with his HM(cell matrix duplication) study. --------------------------------

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