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Topic M456 - Hair Multiplication & Other Advanced Treatments (forum # 41)

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Re: Reply point number 5

From: James Bond
Date: 05 Aug 2001
Time: 22:34:28
Remote Name: 63.10.223.220

Comments

Hi David,

That is a great post! It has stimilated my interest a great deal. I'll have to reply to the 5 points in separate posts and spread out over time. I might as well start with number 5 because it is easiest for me.

>>>>5) Since Dr. Gho uses "Epidermal Stem Cells" according to the patent, it would be helpful if someone can confirm "Epidermal Stem Cells" are equivalent to the stem cells at the bulge region of the follicle.>>>>

Well I think they are the closest known thing: Read the title of this link:

http://www.pnas.org/cgi/content/full/97/25/13473

They basically say that the "ultimate" epidermal stem cell is suspected to be the stem cell inside the follicle bulge.

"These data suggest that the bulge represents a major repository of skin keratinocyte stem cells that may be bipotent because they can give rise not only to the hair follicle (pathway 1 in Fig. 1), but also to the epidermis (pathway 2). Thus, some of the confusion about the in vivo location of epidermal stem cells can be resolved if one hypothesizes that (i) the follicular bulge is the repository of the ultimate stem cells of the interfollicular epidermis, and that (ii) the bulge stem cells give rise to TA cells with a continuum of decreasing proliferative potential. Young TA cells that have arrived in the epidermis can still have an impressive proliferative potential and may be considered progenitor cells."

But get this: "The bulge contains a population of putative keratinocyte stem cells that can give rise to (pathway 1) a population of pluripotent and rapidly dividing progenitor (transit amplifying) cells in the matrix that yields the hair shaft."

Pluripotent is defined as: "Cells in a stem cell line capable of differentiating into several different final differentiated types."

Hence my interest in this particular cell type. Your response to my theory brings up some very interesting points that must be explained though.

jb

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