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From: Common Sense
Date: 11/19/2002
Time: 1:50:27 PM
Remote Name: 24.205.223.116
Yes, Mike, frankly minoxadil has been a big disappointment to me, not just because we all had hopes for it, but also because I spent so much time working with pharmacists and lots of trial and error with various formulations with patients.
I did one small study adding DMSO, a very potent solvent, to assure deep delivery to the follicles. The problem was that the DMSO worked so well that all of the men had side effects from the minoxadil (mainly palpitations and even some shest pain and sensation of shortness of breath--I imagine some people here have probably experienced the same by using too much or too frequently). Later, I was probably one of the first to experiment by adding one cc of Retin A solution to each bottle of Rogaine. I prescribed it this way to hundreds of patients! I think it definitely helps with penetration and results. But, the bottom line (for me) is that even with Retin A, the results are not adequate. If it has given good results to anyone here, I am happy for them, but I am convinced it doesn't work NEAR to the degree that Upjohn's literature suggests it does. I am convinced that hair follicle enhancers that don't deal with the genetic or androgenic cause of MPB will never give significant sustained results for most men. And, yes, applying the minoxadil/retin a combo to damp scalp further aids penetration.
As I and others have said here before, the essential problem with topicals is that not only do they have to address DHT, they have to go deep enough, stay around deep enough, and be applied anywhere the follicles are even beginning to atrophy. A tall order. I do look forward to tryiny topical Dut only because we know the oral will be knocking most of the systemic and local DHT down, and the topical will only be required to do some minimal cleanup.
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